GLP-1 Treatment
Southlake & DFW Area
At Medrein Health & Aesthetics in Southlake, TX, we offer GLP-1 also commonly known as Ozempic or Wegovy, for faster and results driven weight loss.
What is GLP-1?
GLP-1 (Glucagon-Like Peptide-1) receptor agonist that helps regulate blood sugar levels, appetite, and metabolism.
It is FDA-approved for type 2 diabetes management and chronic weight management by promoting weight loss, reducing hunger, and improving insulin sensitivity.
GLP-1, classified as a glucagon-like peptide-1 (GLP-1) receptor agonist, has become a crucial tool in treating type 2 diabetes and obesity. Through its enhancement of incretin function, GLP-1 delivers significant therapeutic advantages. The fact that GLP-1 is accessible in two different forms—an injectable solution for subcutaneous use and an oral tablet—offers healthcare professionals the flexibility to tailor treatment plans to each patient’s unique needs.
- Ozempic® (GLP-1): Ozempic has received FDA approval, establishing itself as a trusted choice for managing diabetes. Adults with known heart disease can benefit from Ozempic® as it lowers the risk of major cardiovascular events, including strokes, heart attacks, and fatalities. This medication, when used in conjunction with diet and exercise, effectively helps patients maintain healthy blood sugar levels, improve their overall well-being, and may have a positive impact on weight; however, it is not specifically intended as a weight loss drug.
- Wegovy® (GLP-1): It is FDA-approved and serves as a reliable weight loss solution. WEGOVY® (GLP-1) injection 2.4 mg is a prescription injectable that can aid adults and adolescents aged 12 and above struggling with obesity (adults with a BMI of 30 or higher, and children with a BMI in the 95th percentile or above for their age and sex), as well as certain adults dealing with excess weight (BMI of 27 or more). This medication, when used in conjunction with a calorie-controlled meal plan and increased physical activity, can be a valuable tool to facilitate weight loss and long-term weight management.
Understanding How GLP-1 Operates
Activation of GLP-1 Receptors
GLP-1’s mechanism of action centers on its interaction with GLP-1 receptors. Acting as a GLP-1 receptor agonist, GLP-1 binds to these receptors, increasing insulin secretion. Importantly, this secretion occurs in a glucose-dependent manner. Additionally, GLP-1 receptors inhibits the release of glucagon, a hormone responsible for elevating blood glucose levels.
Regulating Hepatic Gluconeogenesis
By activating the GLP-1 receptor, GLP-1 effectively dampens hepatic gluconeogenesis—a process wherein the liver generates glucose. This action contributes significantly to reducing both fasting and postprandial glucose levels, representing a noteworthy achievement in managing diabetes.
Activation of GLP-1 Receptors
GLP-1’s effects extend to the digestive system, slowing gastric emptying. This action results in a more gradual appearance of glucose in the bloodstream following a meal, aiding in the more effective management of postprandial glucose levels.
Pharmacodynamics of GLP-1
- Emulating the Effects of GLP-1
GLP-1 operates by mimicking the actions of GLP-1, a naturally occurring hormone crucial for regulating blood glucose levels. It achieves this by promoting insulin secretion and reducing glucagon secretion, particularly when blood glucose levels are elevated. In doing so, GLP-1 assists in maintaining a balanced glucose profile.
- Impact on Insulin Resistance
Clinical studies have revealed that GLP-1 not only leads to reductions in HbA1c levels and body weight in patients with uncontrolled type 2 diabetes but also improves insulin resistance. This positive outcome is primarily attributed to the weight loss associated with GLP-1 therapy, underscoring its dual role in effectively managing both diabetes and obesity.
GLP-1’s Consistency and Prolonged Activity
Achieving Consistency
GLP-1 reaches a consistent state in the body after just two weekly doses, with 75% of this state achieved within two weeks. In the case of the oral tablet formulation, a steady-state concentration is achieved within 4-5 weeks.
Extended Duration of Action
With a half-life of approximately seven days and an action duration of 63.6 hours, GLP-1 maintains its effectiveness in the body for up to a week following administration. This prolonged therapeutic effect sets GLP-1 apart from other GLP-1 receptor agonists.
Potential Adverse Effects and Contraindications of GLP-1
While GLP-1 is recognized for its effectiveness in managing blood sugar levels and promoting weight loss, it’s essential to be aware of potential side effects.
These can vary from common gastrointestinal problems to less common but more serious issues such as severe hypoglycemia or acute pancreatitis.
How Does GLP-1 Work?
GLP-1 works in several ways to promote weight loss:
- Reduces appetite: It slows down stomach emptying and increases feelings of fullness, leading to reduced calorie intake.
- Regulates blood sugar: It helps improve blood sugar control, which can be beneficial for people with type 2 diabetes.
- May reduce cravings: Some people report that GLP-1 helps reduce cravings for unhealthy foods.
Benefits of GLP-1
- Significant weight loss: Clinical trials have shown that GLP-1 can help people achieve significant weight loss, with an average of 15-20% of body weight lost over 68 weeks.
- Improved health: GLP-1 can also help improve blood sugar control, reduce blood pressure, and lower the risk of heart disease.
- Convenient: GLP-1 is an injectable medication administered once a week, making it easy to incorporate into your lifestyle.
Who is a Good Candidate for GLP-1?
GLP-1 may be a good option for you if:
- You have a BMI of 30 or higher (obesity)
- You have a BMI of 27 or higher (overweight) with at least one weight-related condition
- You have tried other weight loss methods without success
- You are committed to making lifestyle changes, including diet and exercise
FAQs
What are the side effects of GLP-1?
Common side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain. These side effects are usually mild and temporary.
Is GLP-1 safe?
GLP-1 is generally safe for most people. However, it is important to talk to your doctor about your medical history and any medications you are taking before starting GLP-1.
How much does GLP-1 cost?
The cost of GLP-1 varies depending on your insurance coverage and the pharmacy you use.
How do I get started with GLP-1?
Contact Medrein Health & Aesthetics in Southlake, TX to schedule a consultation. Our healthcare providers will assess your needs and determine if GLP-1 is right for you.
How long does it take to see results with GLP-1?
Most people begin to see weight loss and blood sugar improvements within a few weeks, with full effects typically seen after 3 to 6 months of consistent use.
Can GLP-1 be combined with other weight loss treatments?
Yes, GLP-1 can be combined with lifestyle modifications, exercise, and other medical treatments under the guidance of a healthcare provider to enhance weight loss results.
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