Semaglutide for Weight Loss in Southlake, TX
One injection a week that takes the edge off appetite. Dr. Mikki checks it fits your history first, then sets the dose to how you respond.
- Google 4.8★
- Yelp 5.0★
What semaglutide does
Semaglutide is one of three GLP-1 medications used for Medical Weight Loss at Medrein. It reduces appetite and slows how fast the stomach empties, so you feel full on less food. You give yourself the injection once a week at home.
What to know before you start
How a GLP-1 signals appetite
GLP-1 is a hormone your small intestine already makes when you eat. Semaglutide copies that signal and holds it for longer. It stays active for about a week, which is why the injection is weekly. It does four things at once.
Ozempic, Wegovy and semaglutide
Most people arrive knowing a brand name. Semaglutide is the molecule inside two of them. What separates Ozempic from Wegovy is what each one is approved to treat.
Ozempic
FDA-approved for managing type 2 diabetes
It also lowers the risk of major cardiovascular events, including strokes and heart attacks. It can have a positive effect on weight, but it is not specifically intended as a weight-loss drug.
Wegovy
FDA-approved for weight loss
A prescription injectable for adults and adolescents aged 12 and above living with obesity, and for certain adults carrying excess weight alongside a weight-related condition.
What a Medrein plan adds to the medication
Semaglutide is one medication inside Medrein's Medical Weight Loss program. Dr. Mikki starts you at a low dose and checks your response at each follow-up. If one receptor is not enough, she may discuss tirzepatide, which adds a second one.
| Feature | Medrein | Mail-Order GLP-1 |
|---|---|---|
| Candidacy confirmed at an in-person consultation | Included | Not included |
| Dose raised at follow-up when you are not responding | Included | Varies |
| Injection technique taught in person | Included | Not included |
| Side effects addressed at the next monthly visit | Included | Varies |
What a semaglutide program looks like
Consultation and candidacy
Dr. Mikki reviews your full medical history, your current medications and any previous weight-loss attempts. She screens for the conditions that rule semaglutide out, and confirms candidacy at that visit.
Baseline labs
Metabolic bloodwork is drawn before anything is prescribed. It gives the program a starting line. It also catches the problems that make weight loss harder if they go untreated: thyroid function, hormone imbalance, nutritional deficiency.
Start low, go slow
You begin at the lowest effective dose and step up gradually. That is what keeps the early nausea manageable. Dr. Mikki teaches you the weekly injection technique in person.
Monthly review
You are seen every month. Each visit checks weight, vitals, appetite, energy and side effects. Labs are repeated when they are due, and the dose is set to how you have actually responded.
A maintenance plan
Reaching your goal starts the next part of the plan. Before you stop, Dr. Mikki works out what keeps the weight off: a lower continuing dose, a different therapy, or the lifestyle changes the program built.
Safety and side effects
What makes the program safe
- Semaglutide is sold as Ozempic, FDA-approved for type 2 diabetes, and as Wegovy, FDA-approved for weight loss.
- Dr. Mikki, a board-certified physician, reviews your history and current medications before the first prescription is written.
- Baseline labs are drawn first and repeated during the program.
- The dose starts low and steps up gradually, which is what keeps most of the early side effects mild.
- You are seen monthly, so a side effect gets addressed at the next visit.
Possible side effects
- Nausea, vomiting, diarrhea, constipation or abdominal pain are the common ones, and they are usually mild and temporary.
- Some patients get headaches, indigestion, dizziness, or a loss of appetite beyond what is useful.
- The injection site can redden or itch.
- Rarely, patients develop pancreatitis, sudden kidney problems, worsening diabetic eye disease, or an allergic reaction.
- Blood sugar can drop too low, particularly alongside other diabetes medication.
Who semaglutide is for
Dr. Mikki confirms candidacy against your history at consultation. She will say plainly when a different route fits better: a dual agonist where one receptor has not been enough, or Hormone Replacement Therapy where the block is hormonal instead of appetite-driven.
A good fit
- Your BMI is over 31, or over 27 alongside a weight-related medical condition.
- Diet and exercise alone have not moved the number, or have not held it.
- You want appetite treated as biology.
- You are willing to be seen monthly and to have labs drawn along the way.
- You have type 2 diabetes or prediabetes alongside the weight, where blood sugar matters as much as the scale.
Not the right treatment
- You have a personal or family history of medullary thyroid cancer, or of Multiple Endocrine Neoplasia type 2.
- Gastroparesis or another significant stomach-emptying problem rules the medication out.
- A history of pancreatitis or reduced kidney function needs a conversation with Dr. Mikki before anything is prescribed.
- You are pregnant, or planning a pregnancy.
- You want a fast result. The dose steps up over weeks and the change is gradual.
Three things worth knowing before you book
Cost depends on your insurance coverage and the pharmacy, so ask for the numbers at consultation. Stopping matters as much as starting: appetite generally returns and weight can come back, which is why the maintenance plan is built in from the first visit. And the change is gradual. Results may vary, and Dr. Mikki sets a realistic timeline for your case at the first visit.
Dr. Mikki takes your history, screens for the conditions that rule semaglutide out, and orders baseline labs. You leave knowing whether this medication fits you and what the first three months look like.
What to expect, and how long it takes
Clinical trials show an average of 15 to 20% of body weight lost over 68 weeks. That is a trial average, not a promise: individual results vary with your starting point, your labs and how consistently the plan is followed. Dr. Mikki's guide to GLP-1 and GIP compared sets the evidence side by side.
Weeks 1–2
Appetite starts to quiet
The first thing most patients notice is that they are less hungry. Mild nausea is common in this window and usually settles.
Weeks 4–8
The new normal
Reduced appetite stops feeling like a side effect and starts feeling ordinary. Portion sizes settle without a running argument at every meal.
Weeks 12–16
Measurable change
Weight loss becomes measurable on the scale. By this point the dose has usually been adjusted at least once.
Months 4–6
Visible change
Full effect typically arrives after three to six months of consistent use. Emotional eating triggers do not disappear along the way, and the coaching side of the program is aimed squarely at those.
Beyond the scale
- Blood sugar stabilizes, and some patients with prediabetes see it return to normal range.
- Blood pressure and cholesterol often improve alongside the weight.
- Better sleep, steadier energy and clearer thinking are commonly reported.
- Joint pain frequently eases as load comes off.
What semaglutide patients say
These illustrate common patient sentiment. They are not word-for-word quotes, and individual results vary.
Dr. Mikki started me on the lowest dose of semaglutide and explained why we were stepping it up slowly instead of rushing. When the nausea showed up she adjusted the plan instead of telling me to tough it out. Results may vary, but I always understood what I was taking and why.
A weekly injection I could do at home, and a physician who changed the dose when my body did.
Frequently asked questions
How does semaglutide work?
Semaglutide copies GLP-1, a gut hormone your body releases when you eat. It reduces appetite and slows how quickly the stomach empties, so you feel full on less food. Dr. Mikki, a board-certified physician, prescribes it and sets the dose at every visit.
How is semaglutide taken?
Semaglutide is a once-weekly injection given under the skin. Dr. Mikki starts you on a low dose and steps it up over several weeks to reduce side effects.
How is semaglutide different from tirzepatide?
Semaglutide acts on one receptor, GLP-1. Tirzepatide acts on two, GLP-1 and GIP. Neither is automatically the right choice. Dr. Mikki matches the medication to your history and how you respond, and she adjusts the plan at follow-up.
Who is a candidate for semaglutide?
Candidacy depends on your BMI, your health history, and any weight-related conditions. Dr. Mikki confirms it and screens for contraindications at your consultation.
How soon will I see results?
The dose steps up over several weeks, so the change is gradual. Most patients notice their appetite quieten in the first two weeks, and weight change becomes measurable around the three-month mark. Results may vary.
Where does Medrein source the medication?
Medrein prescribes through reputable compounding pharmacies. Dr. Mikki checks your response at each follow-up and manages side effects as they come up.
How do I get started?
Book a consultation online or call (214) 702-5225. Dr. Mikki reviews your history, confirms whether semaglutide fits you, and sets your starting dose at that visit.
What are the side effects of semaglutide?
The common ones are gastrointestinal: nausea, vomiting, diarrhea, constipation and abdominal pain. They are usually mild and temporary, most often in the first weeks while the dose is stepping up. Less common are headaches, indigestion, dizziness and injection-site redness. Rarely, pancreatitis, sudden kidney problems, worsening diabetic eye disease or an allergic reaction can occur. Dr. Mikki checks side effects at every monthly visit and adjusts the plan.
Who should not take semaglutide?
Semaglutide is not prescribed to anyone with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia type 2, or to anyone with a significant stomach-emptying problem such as gastroparesis. If you have a history of pancreatitis or reduced kidney function, that needs a conversation with Dr. Mikki before anything is prescribed. She screens for all of it at consultation.
See if semaglutide is right for you
Dr. Mikki reviews your history, confirms candidacy, and sets your starting dose before anything is prescribed.
4.8★ from 128 verified Google reviews